Toxicity of aliphatic nitrile compounds

Electron Spin Resonance Spectra of Aliphatic Nitrile Radicals

A method which has been widely used to study the electron spin resonance (ESR) spectra of transient free radicals in solution is the continuous flow technique, which was first used in investigating peroxidase-substrate oxidations1. The technique was d e v e l o p e d b y DIXON a n d N O R M A N 2 , w h o a l l o w e d aqueous acidic solutions of titanous chloride and hydrogen peroxide to mix im...

Allyl nitrile: Toxicity and health effects

OBJECTIVES Allyl nitrile (3-butenenitrile) occurs naturally in the environment, in particular, in cruciferous vegetables, indicating a possible daily intake of the compound. There is no report on actual health effects of allyl nitrile in humans, although it is possible that individuals in the environment are at a risk of exposure to allyl nitrile. However, little is known about its quantitative...

Structure–Toxicity Relationships for Aliphatic Compounds Based on Correlation Weighting of Local Graph Invariants

Quantitative Structure-Activity Relationships based on molecular descriptors calculated with Correlation Weights of Local Graph Invariants were developed to model the toxicity of aliphatic compounds to the 50% population growth inhibition. The relationships were computed on the basis of Labeled HydrogenFilled Graphs and correlation weights were obtained by an optimization to render as large as ...

Quantitative structure-activity relationships for toxicity and genotoxicity of halogenated aliphatic compounds: wing spot test of Drosophila melanogaster.

Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, ep...

ES Critical Reviews: Transformations of halogenated aliphatic compounds.